Compound Detail
CHEMBL1556
INOSINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL1556 |
| Name | INOSINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | UGQMRVRMYYASKQ-KQYNXXCUSA-N |
1
Targets
5
Activities
2
Assay Types
2
PK Parameters
20
Publications
7
Known Names
14
Indications
Molecular Properties
268.2
MW (Da)
-2.27
ALogP
8
HBA
4
HBD
133.5
PSA (Ų)
0.48
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Diabetic Neuropathies Eye Diseases Jaundice, Obstructive Parkinson Disease Stroke Virus Diseases Amyotrophic Lateral Sclerosis Multiple Sclerosis, Relapsing-Remitting Multiple System Atrophy Myocardial Infarction Neoplasms Triple Negative Breast Neoplasms HIV Infections Melanoma
ATC Classification
D06BB05
inosine
Level 1: DERMATOLOGICALS
Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
G01AX02
inosine
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
S01XA10
inosine
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
Ki 3 meas.
IC50 2 meas. best 9.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vero CHEMBL391 | IC50 | 9.64 | 9.64 | 0.2 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 7.5 | hr | Homo sapiens |
| T1/2 | 5.0 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vero | IC50 | = | 0.23 | nM | 9.64 | Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition ... | 10464017 |
Literature References
Data from ChEMBL 36 via Core Engine