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Compound Detail

CHEMBL157729

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Cc1ccc2nc[nH]c2c1

Basic Information

ChEMBL ID CHEMBL157729
Phase Preclinical
Structure Type MOL
InChI Key RWXZXCZBMQPOBF-UHFFFAOYSA-N
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

132.2
MW (Da)
1.87
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.58
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C8H8N2
MW 132.17
Aromatic Rings 2
Heavy Atoms 10
NP-Likeness -1.47

Activity Summary

IC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C5MD00293A NON-PROTEIN TARGET 2
7120277 10.1021/jm00350a002 Cytochrome P450 2B1 1
7120277 10.1021/jm00350a002 No relevant target 1
7097715 10.1021/jm00348a003 Cytochrome P450 1A1 1
7097715 10.1021/jm00348a003 Cytochrome P450 2B1 1
17379526 10.1016/j.bmc.2007.03.010 Xanthine dehydrogenase/oxidase 1
24262887 10.1016/j.bmc.2013.10.037 Indoleamine 2,3-dioxygenase 1 1
- 10.1039/C5MD00293A CCRF-CEM 1
- 10.1039/C5MD00293A SR 1
- 10.1039/C5MD00293A MCF7 1

Data from ChEMBL 36 via Core Engine