Compound Detail
CHEMBL158139
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL158139 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CJOWDGQKVQMHOD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
448.5
MW (Da)
4.87
ALogP
7
HBA
0
HBD
93.1
PSA (Ų)
0.42
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 6.06 | 6.06 | 871.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 3660.0 | ng.hr.mL-1 | Canis lupus familiaris |
| CL | 10.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| F | 45.4 | % | Canis lupus familiaris |
| T1/2 | 2.7 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 870.96 | nM | 6.06 | Inhibition of FTase | 16455255 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14736242 | 10.1021/jm030434f | Canis familiaris | 4 |
| 14736242 | 10.1021/jm030434f | Protein farnesyltransferase | 2 |
| 14736242 | 10.1021/jm030434f | Geranylgeranyl transferase type I | 1 |
| 16455255 | 10.1016/j.bmcl.2006.01.019 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine