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Compound Detail

CHEMBL159226

MOXISYLYTE
💊 Approved Drug
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💊 Approved Drug
CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL159226
Name MOXISYLYTE
Phase Approved
Structure Type MOL
InChI Key VRYMTAVOXVTQEF-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Carlytene Erecnos Moxisilita Moxisylyte Moxisylyte hcl Moxisylyte hydrochloride Moxivig NSC-170448 Thymoxamine hcl Thymoxamine hydrochloride
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
10
Known Names
2
Indications
1
Mechanisms

Molecular Properties

279.4
MW (Da)
2.98
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.59
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Withdrawn
Chirality Achiral

Routes of Administration

Oral

Flags

Withdrawn Natural Product

Extended Properties

Molecular Formula C16H25NO3
MW 279.38
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness -0.30

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Adrenergic receptor alpha antagonist ANTAGONIST Adrenergic receptor alpha ✓ ✓

Indications

Cardiovascular Diseases Erectile Dysfunction

ATC Classification

C04AX10
moxisylyte
Level 1: CARDIOVASCULAR SYSTEM
Level 2: PERIPHERAL VASODILATORS
G04BE06
moxisylyte
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: UROLOGICALS

Drug Warnings

Withdrawn
hepatotoxicity
dose-dependent hepatotoxicity
Country: France   Year: 1993
Withdrawn
hepatotoxicity
dose-dependent hepatotoxicity
Country: France   Year: 1993

Activity Summary

Kd 2 meas. best 7.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha
CHEMBL2095203
 Kd 7.5 7.5 31.6 1
Adrenergic receptor alpha-2
CHEMBL2095158
 Kd 4.5 4.5 31622.8 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Adrenergic receptor alpha Kd = 31.62 nM 7.5 In vitro relative blocking action (pA2) of the post-synaptic Alpha-1 adrenergic ... 6124636
Adrenergic receptor alpha-2 Kd = 31622.78 nM 4.5 In vitro for relative blocking action (pA2) of Presynaptic Alpha-2 adrenergic re... 6124636

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885861 Rattus norvegicus 1376
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
19397318 10.1021/jm9003945 No relevant target 4
34547896 10.1021/acs.jmedchem.1c00823 Transthyretin 4
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 3
37468498 10.1038/s41467-023-40064-9 Beta-1 adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Beta-2 adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2

Data from ChEMBL 36 via Core Engine