Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1595

DIHYDROCODEINE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
COc1ccc2c3c1O[C@H]1[C@@H](O)CC[C@H]4[C@@H](C2)N(C)CC[C@@]341
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1595
Name DIHYDROCODEINE
Phase Approved
Structure Type MOL
InChI Key RBOXVHNMENFORY-DNJOTXNNSA-N
Therapeutic ✓ Yes

Known Names

.alpha.-hydrocodol 8,14-dihydroneopine Codhydrine Dehacodin Dh-codeine Dihidrocodeina Dihydrocodeine IDS-ND-008(SECT.2) Novicondin NSC-231319 Rapacodin Remedacen
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
12
Known Names
1
Indications

Molecular Properties

301.4
MW (Da)
1.73
ALogP
4
HBA
1
HBD
41.9
PSA (Ų)
0.86
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1983
Availability Discontinued
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product

Extended Properties

Molecular Formula C18H23NO3
MW 301.39
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness 1.97

Indications

Pain

ATC Classification

N02AA08
dihydrocodeine
Level 1: NERVOUS SYSTEM
Level 2: ANALGESICS
N02AA58
dihydrocodeine, combinations
Level 1: NERVOUS SYSTEM
Level 2: ANALGESICS

Literature References

PubMed DOI Target Context # Activities
24183585 10.1016/j.bmc.2013.09.062 Unchecked 3
24183585 10.1016/j.bmc.2013.09.062 Kappa-type opioid receptor 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
24183585 10.1016/j.bmc.2013.09.062 Delta-type opioid receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 2
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 2
24183585 10.1016/j.bmc.2013.09.062 Mu-type opioid receptor 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
20185316 10.1016/j.bmc.2010.01.068 Plasmodium falciparum 1
20185316 10.1016/j.bmc.2010.01.068 Pneumocystis carinii 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma cruzi 1
20022146 10.1016/j.ejmech.2009.11.034 Homo sapiens 1

Data from ChEMBL 36 via Core Engine