Compound Detail
CHEMBL1622565
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Basic Information
| ChEMBL ID | CHEMBL1622565 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QAIDAYZZJYOOJH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
314.8
MW (Da)
5.48
ALogP
3
HBA
0
HBD
25.8
PSA (Ų)
0.64
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 2 CHEMBL1795166 | IC50 | 4.97 | 4.97 | 10700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 2 | IC50 | = | 10700.0 | nM | 4.97 | Inhibition of SREBP2 activation expressed in CHO-K1 cells co-transfected with pS... | 21561152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24967731 | 10.1021/jm500833f | Mycobacterium tuberculosis | 2 |
| 21561152 | 10.1021/jm200304y | Sterol regulatory element-binding protein 2 | 1 |
| 24967731 | 10.1021/jm500833f | No relevant target | 1 |
| 24967731 | 10.1021/jm500833f | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine