Compound Detail
CHEMBL163658
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C[C@@H]1CN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1
Basic Information
| ChEMBL ID | CHEMBL163658 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HVHGZTFFYDUNRF-RPWUZVMVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
611.8
MW (Da)
4.17
ALogP
8
HBA
0
HBD
96.5
PSA (Ų)
0.39
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 9.1 | 9.1 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Ki | = | 0.8 | nM | 9.1 | Binding affinity against human cloned Muscarinic acetylcholine receptor M2. | 11859004 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11859004 | 10.1016/s0960-894x(02)00023-9 | Muscarinic acetylcholine receptor M2 | 1 |
| 11859004 | 10.1016/s0960-894x(02)00023-9 | Muscarinic acetylcholine receptor M1 | 1 |
Data from ChEMBL 36 via Core Engine