Compound Detail
CHEMBL1642577
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Basic Information
| ChEMBL ID | CHEMBL1642577 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OIMQPJMOLJDPEE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
399.5
MW (Da)
5.19
ALogP
6
HBA
0
HBD
48.0
PSA (Ų)
0.39
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | IC50 | 7.12 | 7.12 | 76.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | IC50 | = | 76.0 | nM | 7.12 | Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillatio... | 21087867 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21087867 | 10.1016/j.bmc.2010.10.038 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 1 |
Data from ChEMBL 36 via Core Engine