Compound Detail
CHEMBL1645097
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Basic Information
| ChEMBL ID | CHEMBL1645097 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGOZUAZRHLCAFI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
228.2
MW (Da)
1.13
ALogP
4
HBA
2
HBD
94.9
PSA (Ų)
0.81
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform CHEMBL3145 | IC50 | 4.32 | 4.32 | 48000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | IC50 | = | 48000.0 | nM | 4.32 | Inhibition of human PI3K p110beta catalytic subunit by AlphaScreen competition a... | 21169017 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21169017 | 10.1016/j.bmcl.2010.11.087 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 21169017 | 10.1016/j.bmcl.2010.11.087 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 |
| 21169017 | 10.1016/j.bmcl.2010.11.087 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 21169017 | 10.1016/j.bmcl.2010.11.087 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 |
Data from ChEMBL 36 via Core Engine