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Compound Detail

CHEMBL1651913

OXYFEDRINE
🧪 Phase II
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🧪 Phase II
COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1651913
Name OXYFEDRINE
Phase Phase II
Structure Type MOL
InChI Key GDYUVHBMFVMBAF-LIRRHRJNSA-N

Known Names

(-)-oxyfedrine Oxifedrina Oxyfedrine
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
3
Known Names
1
Indications

Molecular Properties

313.4
MW (Da)
2.98
ALogP
4
HBA
2
HBD
58.6
PSA (Ų)
0.74
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer
USAN Stem -drine

Extended Properties

Molecular Formula C19H23NO3
MW 313.40
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.40

Indications

Cardiovascular Diseases

ATC Classification

C01DX03
oxyfedrine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
C01DX53
oxyfedrine, combinations
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
37468498 10.1038/s41467-023-40064-9 Sodium-dependent serotonin transporter 1
37468498 10.1038/s41467-023-40064-9 D(3) dopamine receptor 1
37468498 10.1038/s41467-023-40064-9 Vascular endothelial growth factor receptor 2 1
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 1
37468498 10.1038/s41467-023-40064-9 Amine oxidase [flavin-containing] A 1
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 1
20022146 10.1016/j.ejmech.2009.11.034 Homo sapiens 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 Estrogen receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 1
- 10.1101/2020.04.21.054387 SARS-CoV-2 1

Data from ChEMBL 36 via Core Engine