Compound Detail
CHEMBL1652606
CEFTOBIPROLE MEDOCARIL FREE ACID 💊 Approved Drug
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💊 Approved Drug
Cc1oc(=O)oc1COC(=O)N1CC[C@@H](N2CC/C(=C\C3=C(C(=O)O)N4C(=O)[C@@H](NC(=O)/C(=N/O)c5nsc(N)n5)[C@H]4SC3)C2=O)C1
Basic Information
| ChEMBL ID | CHEMBL1652606 |
| Name | CEFTOBIPROLE MEDOCARIL FREE ACID |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HFTSMHTWUFCYMJ-FDNJTQOMSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL520642 |
0
Targets
0
Activities
0
Assay Types
1
PK Parameters
8
Publications
3
Known Names
1
Indications
Molecular Properties
690.7
MW (Da)
-0.54
ALogP
16
HBA
4
HBD
264.3
PSA (Ų)
0.09
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2024 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections
ATC Classification
J01DI01
ceftobiprole medocaril
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Vd | 18.4 | l | Homo sapiens |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19470504 | 10.1128/aac.00084-09 | Staphylococcus aureus | 3 |
| 19470504 | 10.1128/aac.00084-09 | Penicillin-binding protein 1 | 1 |
| 19470504 | 10.1128/aac.00084-09 | Penicillin-binding protein 2 | 1 |
| 19470504 | 10.1128/aac.00084-09 | Penicillin-binding protein 2b | 1 |
| 19470504 | 10.1128/aac.00084-09 | Penicillin-binding protein 4 | 1 |
| 19470504 | 10.1128/aac.00084-09 | MecA | 1 |
| 19470504 | 10.1128/aac.00084-09 | Homo sapiens | 1 |
| 19470504 | 10.1128/aac.00084-09 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine