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Compound Detail

CHEMBL165337

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CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1

Basic Information

ChEMBL ID CHEMBL165337
Phase Preclinical
Structure Type MOL
InChI Key IVZDBPFZFBRDKW-PKTZIBPZSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

555.7
MW (Da)
4.50
ALogP
7
HBA
0
HBD
79.4
PSA (Ų)
0.47
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H41N3O5S
MW 555.74
Aromatic Rings 2
Heavy Atoms 39
NP-Likeness -0.97

Activity Summary

Ki 1 meas. best 8.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 8.89 8.89 1.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11859004 10.1016/s0960-894x(02)00023-9 Muscarinic acetylcholine receptor M2 1
11859004 10.1016/s0960-894x(02)00023-9 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine