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Compound Detail

CHEMBL1672108

TNP-ATP SODIUM
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Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])[C@H]2OC3(O[C@H]21)C([N+](=O)[O-])=CC(=[N+]([O-])[O-])C=C3[N+](=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+]

Basic Information

ChEMBL ID CHEMBL1672108
Name TNP-ATP SODIUM
Phase Preclinical
Structure Type MOL
InChI Key QAALSTRPFRCOGF-WJRMKIIVSA-J
Parent Compound CHEMBL1163419
Active Moiety CHEMBL1163419
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

717.3
MW (Da)
-1.09
ALogP
20
HBA
5
HBD
392.5
PSA (Ų)
0.08
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H12N8Na5O19P3
MW 828.18
Aromatic Rings 2
Heavy Atoms 46
NP-Likeness 0.71

Activity Summary

IC50 2 meas. best 5.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2X purinoceptor 2
CHEMBL2135
IC50 5.4 4.9 4000.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21207957 10.1021/jm1012193 P2X purinoceptor 2 2

Data from ChEMBL 36 via Core Engine