Compound Detail
CHEMBL1672287
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Basic Information
| ChEMBL ID | CHEMBL1672287 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NJODZQDZRIFTHQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
228.2
MW (Da)
2.55
ALogP
3
HBA
0
HBD
36.7
PSA (Ų)
0.65
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 CHEMBL2564 | Ki | 8.8 | 8.8 | 1.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 | Ki | = | 1.6 | nM | 8.8 | Displacement of [3H]MPEP from mGluR5 in rat brain | 21207959 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21207959 | 10.1021/jm101430m | Metabotropic glutamate receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine