Compound Detail
CHEMBL1683636
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Basic Information
| ChEMBL ID | CHEMBL1683636 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RVWOHCBHAGBLLT-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1472492 |
| Active Moiety | CHEMBL1472492 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
397.7
MW (Da)
7.61
ALogP
1
HBA
0
HBD
8.8
PSA (Ų)
0.19
QED
1
Ro5 Violations
17
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic elongation factor 2 kinase CHEMBL5026 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic elongation factor 2 kinase | IC50 | = | 60.0 | nM | 7.22 | Inhibition of eEF2K (unknown origin) | 32717479 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31191861 | 10.1039/C8MD00613J | HEK293 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 21324694 | 10.1016/j.bmcl.2011.01.081 | Bacillus subtilis | 1 |
| 21324694 | 10.1016/j.bmcl.2011.01.081 | Escherichia coli | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 32717479 | 10.1016/j.ejmech.2020.112505 | Eukaryotic elongation factor 2 kinase | 1 |
| 39208364 | 10.1021/acs.jmedchem.4c01484 | Eukaryotic elongation factor 2 kinase | 1 |
Data from ChEMBL 36 via Core Engine