Compound Detail
CHEMBL168604
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COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(OCCO)nc1OCCOc1ncc(Br)cn1
Basic Information
| ChEMBL ID | CHEMBL168604 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLDUFPDBOYCOMG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
690.6
MW (Da)
4.76
ALogP
12
HBA
2
HBD
164.1
PSA (Ų)
0.17
QED
2
Ro5 Violations
14
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL4130 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | IC50 | = | 0.2 | nM | 9.7 | In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine a... | 11738578 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11738578 | 10.1016/s0960-894x(01)00682-5 | Endothelin-1 receptor | 1 |
Data from ChEMBL 36 via Core Engine