Compound Detail
CHEMBL1689480
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CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)CSSC[C@@H](C(=O)N[C@@H](C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(N)=O)[C@@H](C)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL1689480 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PSHTWLDWKUGJNS-ZCUGKWHYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
2264.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Placenta growth factor CHEMBL1697670 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Placenta growth factor | IC50 | = | 0.2 | nM | 9.7 | Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA | 21280651 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21280651 | 10.1021/jm101226k | Serum | 2 |
| 21280651 | 10.1021/jm101226k | Placenta growth factor | 1 |
Data from ChEMBL 36 via Core Engine