Compound Detail
CHEMBL1697737
CLOTIAZEPAM 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1697737 |
| Name | CLOTIAZEPAM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | CHBRHODLKOZEPZ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
3
Known Names
1
Indications
1
Mechanisms
Molecular Properties
318.8
MW (Da)
3.78
ALogP
3
HBA
0
HBD
32.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| GABA-A receptor; anion channel positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel | ✓ | ✓ |
Indications
Anxiety
ATC Classification
N05BA21
clotiazepam
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS
Activity Summary
EC50 1 meas. best 6.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 6.74 | 6.74 | 184.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 184.0 | nM | 6.74 | Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S e... | 21793559 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| 21793559 | 10.1021/np200317p | Unchecked | 2 |
| 17544548 | 10.1016/j.ejmech.2007.04.002 | ADMET | 1 |
| 21563811 | 10.1021/np200181d | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine