Compound Detail
CHEMBL170652
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CC(C)(C)NC(=O)N1CCC(CC(=O)N2CCN(C3c4ccc(Cl)cc4CCc4cc(Br)cnc43)CC2)CC1
Basic Information
| ChEMBL ID | CHEMBL170652 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YAYKJZBLFCZGCH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
617.0
MW (Da)
5.44
ALogP
4
HBA
1
HBD
68.8
PSA (Ų)
0.50
QED
2
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 6.97 | 6.97 | 108.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 108.0 | nM | 6.97 | In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene | 9526562 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9526562 | 10.1021/jm970462w | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine