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Compound Detail

CHEMBL170960

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Cc1ccsc1C(C)c1c[nH]cn1

Basic Information

ChEMBL ID CHEMBL170960
Phase Preclinical
Structure Type MOL
InChI Key AOISAOGWBMJBPG-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

192.3
MW (Da)
2.93
ALogP
2
HBA
1
HBD
28.7
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H12N2S
MW 192.29
Aromatic Rings 2
Heavy Atoms 13
NP-Likeness -0.96

Activity Summary

Ki 1 meas. best 9.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1D adrenergic receptor
CHEMBL223
Ki 9.11 9.11 0.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11300868 10.1021/jm0003891 Rattus norvegicus 2
11300868 10.1021/jm0003891 Alpha-1D adrenergic receptor 1

Data from ChEMBL 36 via Core Engine