Compound Detail
CHEMBL1716091
SDX-101 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1716091 |
| Name | SDX-101 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NNYBQONXHNTVIJ-QGZVFWFLSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
8
Known Names
2
Indications
1
Mechanisms
Molecular Properties
287.4
MW (Da)
3.38
ALogP
2
HBA
2
HBD
62.3
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Retinoid X receptor alpha modulator | MODULATOR | Retinoic acid receptor RXR-alpha | ✓ | ✓ |
Indications
Leukemia, Lymphocytic, Chronic, B-Cell Multiple Myeloma
Activity Summary
IC50 3 meas. best 4.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 4.34 | 4.34 | 46000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 46000.0 | nM | 4.34 | Inhibition of Tcf in HEK293 cells by TOPflash luciferase reporter assay | 35581674 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 35581674 | 10.1021/acs.jmedchem.2c00228 | Catenin beta-1 | 2 |
| 26182238 | 10.1021/acs.jmedchem.5b00460 | Unchecked | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 35581674 | 10.1021/acs.jmedchem.2c00228 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine