Compound Detail
CHEMBL172192
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Cc1ccc(CN2CCc3c(c(=O)n(CC4NCCc5ccccc54)c(=O)n3Cc3c(F)cccc3F)C2)c(C)c1
Basic Information
| ChEMBL ID | CHEMBL172192 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HJNWXNGNDDFENS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
556.7
MW (Da)
4.40
ALogP
6
HBA
1
HBD
59.3
PSA (Ų)
0.38
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor CHEMBL1855 | Ki | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | Ki | = | 110.0 | nM | 6.96 | Inhibition of GnRH receptor | 17920281 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17920281 | 10.1016/j.bmc.2007.09.026 | Gonadotropin-releasing hormone receptor | 2 |
Data from ChEMBL 36 via Core Engine