Compound Detail
CHEMBL1738829
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Basic Information
| ChEMBL ID | CHEMBL1738829 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MKSQDWBNZVGINB-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
404.5
MW (Da)
3.12
ALogP
6
HBA
3
HBD
103.0
PSA (Ų)
0.60
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| Tyrosine-protein kinase ITK/TSK CHEMBL2959 | Ki | 7.8 | 7.8 | 16.0 | 1 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | Ki | 7.4 | 7.4 | 40.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | Ki | = | 5.0 | nM | 8.3 | Inhibition of Flt3 after 20 mins by radiometric phosphate incorporation assay | 21391610 |
| Tyrosine-protein kinase ITK/TSK | Ki | = | 16.0 | nM | 7.8 | Inhibition of Itk after 40 mins by radiometric phosphate incorporation assay | 21391610 |
| Proto-oncogene tyrosine-protein kinase Src | Ki | = | 40.0 | nM | 7.4 | Inhibition of Src after 10 mins by radiometric phosphate incorporation assay | 21391610 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21391610 | 10.1021/jm101499u | Unchecked | 3 |
| 21391610 | 10.1021/jm101499u | Tyrosine-protein kinase ITK/TSK | 1 |
| 21391610 | 10.1021/jm101499u | Mast/stem cell growth factor receptor Kit | 1 |
| 21391610 | 10.1021/jm101499u | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 21391610 | 10.1021/jm101499u | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine