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Compound Detail

CHEMBL1765880

CHIMARRHININ
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O=C(O[C@H]1[C@H]([C@@]2(c3ccc(O)c(O)c3)CC[C@H](Cc3ccc(O)c(O)c3)C(=O)O2)OC[C@@H]1O)c1cc(O)cc(O)c1

Basic Information

ChEMBL ID CHEMBL1765880
Name CHIMARRHININ
Phase Preclinical
Structure Type MOL
InChI Key HBIPDNZXAWNFRY-VEKNWUCMSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

568.5
MW (Da)
2.30
ALogP
12
HBA
7
HBD
203.4
PSA (Ų)
0.17
QED
3
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C29H28O12
MW 568.53
Aromatic Rings 3
Heavy Atoms 41
NP-Likeness 1.76

Activity Summary

IC50 1 meas. best 5.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Radical scavenging activity
CHEMBL613712
IC50 5.12 5.12 7500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21341711 10.1021/np1007476 Radical scavenging activity 1

Data from ChEMBL 36 via Core Engine