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Compound Detail

CHEMBL1765958

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C=C(c1ccccc1)[C@@]12CN(Cc3ccccc3)C[C@@H]1CC(CCCCCC)=C2c1ccccc1

Basic Information

ChEMBL ID CHEMBL1765958
Phase Preclinical
Structure Type MOL
InChI Key JFILKYCVXYKAKB-TWJUONSBSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

461.7
MW (Da)
8.65
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.27
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H39N
MW 461.69
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness 0.12

Activity Summary

EC50 1 meas. best 6.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 5 group A member 2
CHEMBL3544
EC50 6.5 6.5 316.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21391689 10.1021/jm1014296 Steroidogenic factor 1 2
21391689 10.1021/jm1014296 Nuclear receptor subfamily 5 group A member 2 2
21391689 10.1021/jm1014296 No relevant target 1

Data from ChEMBL 36 via Core Engine