Compound Detail
CHEMBL1767175
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Basic Information
| ChEMBL ID | CHEMBL1767175 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RZLCKONSWTYTTN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
412.5
MW (Da)
3.10
ALogP
6
HBA
0
HBD
62.5
PSA (Ų)
0.57
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 11000.0 | nM | 4.96 | Inhibition of recombinant HIV1 reverse transcriptase RNase H expressed in Escher... | 30031978 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21381765 | 10.1021/jm1014378 | Unchecked | 2 |
| 30031978 | 10.1016/j.ejmech.2018.07.035 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine