Compound Detail
CHEMBL1773283
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Basic Information
| ChEMBL ID | CHEMBL1773283 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KRCCTTRJUJRZKA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
507.6
MW (Da)
3.85
ALogP
9
HBA
0
HBD
107.3
PSA (Ų)
0.49
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor CHEMBL5652 | EC50 | 9.3 | 9.3 | 0.5 | 1 |
| Glucose-dependent insulinotropic receptor CHEMBL5262 | EC50 | 8.14 | 8.14 | 7.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor | EC50 | = | 0.5 | nM | 9.3 | Agonist activity at human GPR119 by melanophore assay | 21444206 |
| Glucose-dependent insulinotropic receptor | EC50 | = | 7.3 | nM | 8.14 | Agonist activity at rat GPR119 by melanophore assay | 21444206 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21444206 | 10.1016/j.bmcl.2011.03.007 | Glucose-dependent insulinotropic receptor | 4 |
Data from ChEMBL 36 via Core Engine