Compound Detail
CHEMBL1779836
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Basic Information
| ChEMBL ID | CHEMBL1779836 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OCTZUVJXHMADFN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names
Molecular Properties
384.8
MW (Da)
5.26
ALogP
2
HBA
3
HBD
61.4
PSA (Ų)
0.66
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | - | - | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 260.0 | nM | 6.58 | Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin... | 21531136 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21531136 | 10.1016/j.bmcl.2011.04.013 | Transient receptor potential cation channel subfamily V member 1 | 2 |
| 21531136 | 10.1016/j.bmcl.2011.04.013 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine