Compound Detail
CHEMBL1789658
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Basic Information
| ChEMBL ID | CHEMBL1789658 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XOXNEDDHVCBSGK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
202.3
MW (Da)
2.11
ALogP
2
HBA
0
HBD
16.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907589 | Ki | 7.5 | 7.5 | 32.0 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL2492 | Ki | 6.01 | 6.01 | 979.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 | Ki | = | 32.0 | nM | 7.5 | Displacement of [3H]nicotine human alpha4beta2 nAChR in SH-EP1 cell membranes | 23126648 |
| Neuronal acetylcholine receptor subunit alpha-7 | Ki | = | 979.0 | nM | 6.01 | Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cell... | 23126648 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23126648 | 10.1021/jm301048a | Neuronal acetylcholine receptor; alpha4/beta2 | 1 |
| 23126648 | 10.1021/jm301048a | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
Data from ChEMBL 36 via Core Engine