Compound Detail
CHEMBL179173
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Basic Information
| ChEMBL ID | CHEMBL179173 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HNMNAGYJPITMSM-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
388.5
MW (Da)
4.41
ALogP
4
HBA
1
HBD
51.1
PSA (Ų)
0.57
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 7.57 | 7.57 | 27.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 27.0 | nM | 7.57 | Binding affinity against cloned human 5-hydroxytryptamine 6 receptor expressed i... | 15603958 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 27.0 | nM | 7.57 | Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells by ... | 27326337 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15603958 | 10.1016/j.bmcl.2004.10.064 | 5-hydroxytryptamine receptor 6 | 1 |
| 27326337 | 10.1021/acsmedchemlett.6b00056 | 5-hydroxytryptamine receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine