Compound Detail
CHEMBL1800150
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COCCN(C)Cc1c(-c2ccc(NC(=O)NOC)cc2)sc2c1c(=O)n(CCO)c(=O)n2Cc1c(F)cccc1F
Basic Information
| ChEMBL ID | CHEMBL1800150 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FGGWCOLDQRWNMZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
603.6
MW (Da)
2.97
ALogP
10
HBA
3
HBD
127.1
PSA (Ų)
0.21
QED
1
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor CHEMBL1855 | IC50 | 9.52 | 9.52 | 0.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | IC50 | = | 0.3 | nM | 9.52 | Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed... | 21657270 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21657270 | 10.1021/jm200216q | Gonadotropin-releasing hormone receptor | 2 |
| 21657270 | 10.1021/jm200216q | No relevant target | 1 |
| 21657270 | 10.1021/jm200216q | Cytochrome P450 3A4 | 1 |
Data from ChEMBL 36 via Core Engine