Compound Detail
CHEMBL1800670
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CCOCCn1c(=O)c2c(CN(C)CCOC)c(-c3ccc(NC(=O)NOC)cc3)sc2n(Cc2c(F)cccc2F)c1=O
Basic Information
| ChEMBL ID | CHEMBL1800670 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GRKANJRMMDQVRY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
631.7
MW (Da)
4.02
ALogP
10
HBA
2
HBD
116.1
PSA (Ų)
0.16
QED
1
Ro5 Violations
14
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor CHEMBL1855 | IC50 | 9.7 | 9.565 | 0.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | IC50 | = | 0.2 | nM | 9.7 | Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed... | 21657270 |
| Gonadotropin-releasing hormone receptor | IC50 | = | 0.37 | nM | 9.43 | Antagonist activity at human GnRH receptor expressed in CHO cells assessed as in... | 21657270 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21657270 | 10.1021/jm200216q | Gonadotropin-releasing hormone receptor | 2 |
| 21657270 | 10.1021/jm200216q | No relevant target | 1 |
| 21657270 | 10.1021/jm200216q | Cytochrome P450 3A4 | 1 |
Data from ChEMBL 36 via Core Engine