Compound Detail
CHEMBL180822
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Basic Information
| ChEMBL ID | CHEMBL180822 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CQOQGFPPQJNODN-UOFNXBMGSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
189.2
MW (Da)
-1.66
ALogP
4
HBA
4
HBD
120.8
PSA (Ų)
0.42
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 8.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 8 CHEMBL3228 | Kd | 8.2 | 8.2 | 6.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 8 | Kd | = | 6.3 | nM | 8.2 | Dissociation constant of radiolabeled compound against recombinant human Metabot... | 15603952 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15603952 | 10.1016/j.bmcl.2004.10.093 | Metabotropic glutamate receptor 8 | 2 |
Data from ChEMBL 36 via Core Engine