Compound Detail
CHEMBL181279
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Basic Information
| ChEMBL ID | CHEMBL181279 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NJNMSBQJBJTUPG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
406.4
MW (Da)
4.25
ALogP
3
HBA
1
HBD
43.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 9.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kappa-type opioid receptor CHEMBL237 | Ki | 9.36 | 9.36 | 0.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kappa-type opioid receptor | Ki | = | 0.44 | nM | 9.36 | Displacement of bound [3H]diprenorphine from membranes expressing cloned human k... | 15686919 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15686919 | 10.1016/j.bmcl.2004.12.018 | Mus musculus | 4 |
| 15686919 | 10.1016/j.bmcl.2004.12.018 | Kappa-type opioid receptor | 1 |
| 15686919 | 10.1016/j.bmcl.2004.12.018 | Opioid receptors; mu & kappa | 1 |
| 15686919 | 10.1016/j.bmcl.2004.12.018 | Opioid receptors; delta & kappa | 1 |
Data from ChEMBL 36 via Core Engine