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Compound Detail

CHEMBL1813233

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CC(C)C[C@H](NC(=O)[C@@H](N)CC(N)=O)B(O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1813233
Phase Preclinical
Structure Type MOL
InChI Key TVBSJFGNXMUSCO-BQBZGAKWSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

245.1
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H20BN3O4
MW 245.09

Activity Summary

IC50 2 meas. best 7.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 7.2 6.655 63.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 63.0 nM 7.2 Inhibition of chymotrypsin-like activity of 20S proteasome using suc-LLVY-AMC as... 21634429
Unchecked IC50 = 770.0 nM 6.11 Inhibition of chymotrypsin-like activity of 20S proteasome using suc-LLVY-AMC as... 21634429

Literature References

PubMed DOI Target Context # Activities
21634429 10.1021/jm200460q Unchecked 4

Data from ChEMBL 36 via Core Engine