Compound Detail
CHEMBL1824664
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Basic Information
| ChEMBL ID | CHEMBL1824664 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UIQZGUHSTKZKGY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
310.4
MW (Da)
4.83
ALogP
4
HBA
0
HBD
35.0
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 2 CHEMBL1795166 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 2 | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of SREBP2 activation expressed in CHO-K1 cells co-transfected with pS... | 21561152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21561152 | 10.1021/jm200304y | Sterol regulatory element-binding protein 2 | 1 |
| 24967731 | 10.1021/jm500833f | Mycobacterium tuberculosis | 1 |
| 24967731 | 10.1021/jm500833f | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine