Compound Detail
CHEMBL182886
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL182886 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | REDUAMKOTCJQNS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
445.4
MW (Da)
4.42
ALogP
5
HBA
1
HBD
63.7
PSA (Ų)
0.63
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.04 | 7.04 | 91.0 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 6.91 | 6.91 | 124.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 91.0 | nM | 7.04 | Inhibitory activity against Melanin-concentrating hormone receptor 1 | 15225734 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 124.0 | nM | 6.91 | Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MC... | 15225734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15225734 | 10.1016/j.bmcl.2004.05.051 | Unchecked | 2 |
| 15225734 | 10.1016/j.bmcl.2004.05.051 | Melanin-concentrating hormone receptor 1 | 1 |
| 15225734 | 10.1016/j.bmcl.2004.05.051 | 5-hydroxytryptamine receptor 2A | 1 |
| 15225734 | 10.1016/j.bmcl.2004.05.051 | 5-hydroxytryptamine receptor 2B | 1 |
| 15225734 | 10.1016/j.bmcl.2004.05.051 | 5-hydroxytryptamine receptor 2C | 1 |
| 15225734 | 10.1016/j.bmcl.2004.05.051 | D(2) dopamine receptor | 1 |
| 15225734 | 10.1016/j.bmcl.2004.05.051 | Alpha-1A adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine