Compound Detail
CHEMBL1830705
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Basic Information
| ChEMBL ID | CHEMBL1830705 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XVAGDGYSYFRXHH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
283.4
MW (Da)
3.08
ALogP
5
HBA
2
HBD
66.5
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 6.04 | 6.04 | 910.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 400.0 | ml/min | Rattus norvegicus |
| CL | 48.0 | L/min | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 910.0 | nM | 6.04 | Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells as... | 21688779 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21688779 | 10.1021/jm200290z | ADMET | 3 |
| 21688779 | 10.1021/jm200290z | Metabotropic glutamate receptor 4 | 2 |
| 21688779 | 10.1021/jm200290z | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine