Compound Detail
CHEMBL183329
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL183329 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KDVINCOUYWJUMK-CQSZACIVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
313.4
MW (Da)
3.24
ALogP
4
HBA
0
HBD
30.9
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 8.59 | 8.59 | 2.5 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 8.28 | 8.28 | 5.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 2.55 | nM | 8.59 | Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cel... | 20138771 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 5.29 | nM | 8.28 | Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor | 15267230 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15267230 | 10.1021/jm0498102 | 5-hydroxytryptamine receptor 7 | 2 |
| 15267230 | 10.1021/jm0498102 | 5-hydroxytryptamine receptor 1A | 1 |
| 15267230 | 10.1021/jm0498102 | D(2) dopamine receptor | 1 |
| 15267230 | 10.1021/jm0498102 | Unchecked | 1 |
| 20138771 | 10.1016/j.bmc.2010.01.035 | 5-hydroxytryptamine receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine