Compound Detail
CHEMBL183343
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CCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc(O)c2c(CC)nc(C3CCCC3)n2n1
Basic Information
| ChEMBL ID | CHEMBL183343 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VIFBFEHCTFXWRR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
514.6
MW (Da)
3.05
ALogP
9
HBA
1
HBD
113.2
PSA (Ų)
0.51
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 7.0 | nM | 8.15 | Inhibition of phosphodiesterase 5 | 15993055 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15993055 | 10.1016/j.bmcl.2005.05.090 | Phosphodiesterase 1 | 1 |
| 15993055 | 10.1016/j.bmcl.2005.05.090 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine