Compound Detail
CHEMBL1834228
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Basic Information
| ChEMBL ID | CHEMBL1834228 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SNHKXOAXJXJUQK-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
328.8
MW (Da)
1.93
ALogP
3
HBA
1
HBD
74.1
PSA (Ų)
0.68
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 8.2
Ki 1 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Kd | 8.2 | 8.2 | 6.3 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 7.75 | 7.75 | 17.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Kd | = | 6.31 | nM | 8.2 | Antagonist activity at human recombinant 5-HT6 receptor expressed in CHO aequosc... | 21866910 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 17.8 | nM | 7.75 | Displacement of [3H]-methyllysergic acid diethylamide from human 5-HT6 receptor ... | 21866910 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21866910 | 10.1021/jm200466r | 5-hydroxytryptamine receptor 6 | 2 |
Data from ChEMBL 36 via Core Engine