Compound Detail
CHEMBL187073
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Basic Information
| ChEMBL ID | CHEMBL187073 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IPLJODHOBMJVDD-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1181645 |
| Active Moiety | CHEMBL1181645 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
402.9
MW (Da)
4.77
ALogP
5
HBA
1
HBD
57.7
PSA (Ų)
0.72
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL4649 | IC50 | 9.52 | 9.52 | 0.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | IC50 | = | 0.3 | nM | 9.52 | Inhibition of [125I]ovine-CRF binding to corticotropin releasing factor receptor... | 15509177 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15509177 | 10.1021/jm049737f | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine