Compound Detail
CHEMBL189475
LADARIXIN 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL189475 |
| Name | LADARIXIN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | DDLPYOCJHQSVSZ-SSDOTTSWSA-N |
1
Targets
2
Activities
2
Assay Types
5
PK Parameters
20
Publications
4
Known Names
3
Indications
2
Mechanisms
Molecular Properties
375.4
MW (Da)
1.09
ALogP
6
HBA
1
HBD
106.6
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Interleukin-8 receptor A modulator | MODULATOR | C-X-C chemokine receptor type 1 | ✓ | ✓ |
| Interleukin-8 receptor B modulator | MODULATOR | C-X-C chemokine receptor type 2 | ✓ | ✓ |
Indications
Diabetes Mellitus, Type 1 Carcinoma, Non-Small-Cell Lung Pemphigoid, Bullous
Activity Summary
IC50 1 meas. best 9.15
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| C-X-C chemokine receptor type 2 CHEMBL2434 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 0.1 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 3.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| F | 100.0 | % | Rattus norvegicus |
| T1/2 | 19.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| C-X-C chemokine receptor type 2 | IC50 | = | 0.7 | nM | 9.15 | Antagonist activity at CXCR2 (unknown origin) | 36780833 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900265 | 10.1021/ml2001533 | Hepatocyte | 22 |
| 24900265 | 10.1021/ml2001533 | No relevant target | 3 |
| 24900265 | 10.1021/ml2001533 | Rattus norvegicus | 3 |
| 17665889 | 10.1021/jm061469t | Unchecked | 2 |
| 15801837 | 10.1021/jm049227l | Albumin | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL3301361 | ADMET | 2 |
| 36780833 | 10.1016/j.ejmech.2023.115175 | C-X-C chemokine receptor type 2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
| 24900265 | 10.1021/ml2001533 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 24900265 | 10.1021/ml2001533 | Interleukin-8 receptors, CXCR1/CXCR2 | 1 |
| 24900265 | 10.1021/ml2001533 | C-X-C chemokine receptor type 2 | 1 |
| 24900265 | 10.1021/ml2001533 | Cytochrome P450 1A2 | 1 |
| 24900265 | 10.1021/ml2001533 | Cytochrome P450 2D6 | 1 |
| 24900265 | 10.1021/ml2001533 | Cytochrome P450 3A4 | 1 |
| 24900265 | 10.1021/ml2001533 | Cytochrome P450 2C9 | 1 |
| 24900265 | 10.1021/ml2001533 | Cytochrome P450 2C19 | 1 |
| 24900265 | 10.1021/ml2001533 | Plasma | 1 |
| 24900265 | 10.1021/ml2001533 | Liver microsomes | 1 |
Data from ChEMBL 36 via Core Engine