Compound Detail
CHEMBL189547
PLOGLITAZONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL189547 |
| Name | PLOGLITAZONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CZKMWGGUVIBIOI-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
355.5
MW (Da)
3.76
ALogP
4
HBA
1
HBD
55.4
PSA (Ų)
0.82
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.24
Ki 1 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 6.24 | 6.24 | 580.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | Ki | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 580.0 | nM | 6.24 | Effective concentration against human peroxisome proliferator activated receptor... | 15293980 |
| Peroxisome proliferator-activated receptor gamma | Ki | = | 1200.0 | nM | 5.92 | Binding affinity for human peroxisome proliferator activated receptor gamma | 15293980 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15293980 | 10.1021/jm030631e | Peroxisome proliferator-activated receptor alpha | 2 |
| 15293980 | 10.1021/jm030631e | Peroxisome proliferator-activated receptor gamma | 2 |
Data from ChEMBL 36 via Core Engine