Compound Detail
CHEMBL1908906
FLORBETABEN 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1908906 |
| Name | FLORBETABEN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | NCWZOASIUQVOFA-NSCUHMNNSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
2
Known Names
1
Indications
Molecular Properties
359.4
MW (Da)
4.28
ALogP
4
HBA
1
HBD
39.7
PSA (Ų)
0.45
QED
0
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2014 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Alzheimer Disease
Activity Summary
Kd 1 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Kd | 7.8 | 7.8 | 16.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Kd | = | 16.0 | nM | 7.8 | Ex vivo binding affinity to amyloid beta (1 to 42) in 3xTg-AD transgenic APP/PS1... | 33069076 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33069076 | 10.1016/j.bmc.2020.115700 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine