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Compound Detail

CHEMBL1909282

FENCLOZIC ACID
💊 Approved Drug
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💊 Approved Drug
O=C(O)Cc1csc(-c2ccc(Cl)cc2)n1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1909282
Name FENCLOZIC ACID
Phase Approved
Structure Type MOL
InChI Key APBSKHYXXKHJFK-UHFFFAOYSA-N

Known Names

Acide fenclozique Acido fenclozico Fenclozic acid I.C.I. 54,450 ICI-54450
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
9
Publications
5
Known Names
1
Mechanisms

Molecular Properties

253.7
MW (Da)
3.09
ALogP
3
HBA
1
HBD
50.2
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Withdrawn
Chirality Achiral

Flags

Withdrawn

Extended Properties

Molecular Formula C11H8ClNO2S
MW 253.71
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -1.98

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Unknown - - ✓ ✓

Drug Warnings

Withdrawn
hepatotoxicity
Jaundice; Elevated Hepatic Enzymes
Country: United States; United Kingdom   Year: 1970
Withdrawn
hepatotoxicity
Jaundice; Elevated Hepatic Enzymes
Country: United States; United Kingdom   Year: 1970
Withdrawn
hepatotoxicity
Jaundice; Elevated Hepatic Enzymes
Country: United States; United Kingdom   Year: 1970
Withdrawn
hepatotoxicity
Jaundice; Elevated Hepatic Enzymes
Country: United States; United Kingdom   Year: 1970

Literature References

PubMed DOI Target Context # Activities
21965623 10.1124/dmd.111.040758 Bile salt export pump 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
21624500 10.1016/j.drudis.2011.05.007 Hepatotoxicity 1
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 1
- 10.6019/CHEMBL3301361 No relevant target 1
21965623 10.1124/dmd.111.040758 Plasma 1
22961681 10.1124/dmd.112.047068 Bile salt export pump 1
- 10.1101/2020.04.03.023846 SARS-CoV-2 1

Data from ChEMBL 36 via Core Engine