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Compound Detail

CHEMBL1909286

PHENOXYPROPAZINE
💊 Approved Drug
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💊 Approved Drug
CC(COc1ccccc1)NN
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1909286
Name PHENOXYPROPAZINE
Phase Approved
Structure Type MOL
InChI Key QNEXFJFTGQBXBJ-UHFFFAOYSA-N

Known Names

Fenoxipropazina Fenoxypropazine Phenoxypropazine
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
1
Mechanisms

Molecular Properties

166.2
MW (Da)
0.92
ALogP
3
HBA
2
HBD
47.3
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Withdrawn
Chirality Racemic

Flags

Withdrawn Natural Product

Extended Properties

Molecular Formula C9H14N2O
MW 166.22
Aromatic Rings 1
Heavy Atoms 12
NP-Likeness -0.90

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Monoamine oxidase inhibitor INHIBITOR Monoamine oxidase ✓ ✓

Drug Warnings

Withdrawn
General Warning
Hepatotoxicity; Drug Interaction
Country: United Kingdom   Year: 1966
Withdrawn
hepatotoxicity
Hepatotoxicity; Drug Interaction
Country: United Kingdom   Year: 1966
Withdrawn
hepatotoxicity
Hepatotoxicity; Drug Interaction
Country: United Kingdom   Year: 1966

Activity Summary

IC50 1 meas. best 4.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 4.57 4.57 27181.7 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 27181.7 nM 4.57 PubChem BioAssay. GLP1 secretion from STC-1 cells-IC50. (Class of assay: confi... -

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
37468498 10.1038/s41467-023-40064-9 Vascular endothelial growth factor receptor 2 1
37468498 10.1038/s41467-023-40064-9 Amine oxidase [flavin-containing] A 1
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent serotonin transporter 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
21624500 10.1016/j.drudis.2011.05.007 Hepatotoxicity 1
37468498 10.1038/s41467-023-40064-9 Bile salt export pump 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 1

Data from ChEMBL 36 via Core Engine