Compound Detail
CHEMBL191251
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Basic Information
| ChEMBL ID | CHEMBL191251 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DJAHLZXHKVPSHL-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
297.8
MW (Da)
3.52
ALogP
5
HBA
2
HBD
76.7
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.94 | 5.87 | 1148.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1148.15 | nM | 5.94 | Inhibitory concentration (experimental) against vascular endothelial growth fact... | 16033269 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1600.0 | nM | 5.8 | Inhibition of vascular endothelial growth factor receptor 2 | 16033269 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16033269 | 10.1021/jm058205b | Vascular endothelial growth factor receptor 2 | 3 |
| 16033269 | 10.1021/jm058205b | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine