Compound Detail
CHEMBL1916485
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CCCOCCn1c(=O)nc(N[C@@H]2CCCC[C@@H]2C(=O)O)c2nnc(-c3ccc(OC)nc3)cc21
Basic Information
| ChEMBL ID | CHEMBL1916485 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NUOAFYWWCXBAEP-DLBZAZTESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
482.5
MW (Da)
2.74
ALogP
10
HBA
2
HBD
141.3
PSA (Ų)
0.41
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 10.7 | 10.7 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 0.02 | nM | 10.7 | Inhibition of PDE5 | 21955943 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21955943 | 10.1016/j.bmcl.2011.08.106 | Unchecked | 2 |
| 21955943 | 10.1016/j.bmcl.2011.08.106 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine