Compound Detail
CHEMBL1917018
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Basic Information
| ChEMBL ID | CHEMBL1917018 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UMXFNUYGOMFSCY-YHYXMXQVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
260.3
MW (Da)
2.66
ALogP
3
HBA
2
HBD
44.9
PSA (Ų)
0.61
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 6.74 | 6.74 | 184.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 184.0 | nM | 6.74 | Inhibition of recombinant PIM1 (unknown origin) by pyruvate kinase/lactate dehyd... | 28341403 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28531811 | 10.1016/j.ejmech.2017.05.012 | Calf thymus DNA | 4 |
| 22077389 | 10.1021/jm201243p | Unchecked | 3 |
| 28341403 | 10.1016/j.bmc.2017.02.056 | Serine/threonine-protein kinase pim-1 | 2 |
| 21873052 | 10.1016/j.bmcl.2011.07.107 | 80S Ribosome | 1 |
| 22077389 | 10.1021/jm201243p | Prothrombin | 1 |
| 28531811 | 10.1016/j.ejmech.2017.05.012 | HL-60 | 1 |
| 28531811 | 10.1016/j.ejmech.2017.05.012 | K562 | 1 |
| 28531811 | 10.1016/j.ejmech.2017.05.012 | T47D | 1 |
| 28531811 | 10.1016/j.ejmech.2017.05.012 | MCF7 | 1 |
Data from ChEMBL 36 via Core Engine